Sildalis (Sildenafil Citrate 100 mg + Tadalafil 20 mg) – Patient Information (Australia)

Sildalis is a combination medicine that contains sildenafil citrate 100 mg and tadalafil 20 mg. It is used to help men achieve and maintain an erection suitable for sexual activity. This page explains how Sildalis works, how it is typically taken, what to expect, and important safety information for use in Australia.

If you are unsure whether Sildalis is right for you, or you have medical conditions or take other medicines, speak with a qualified healthcare professional or pharmacist for personalised advice.

Quick overview

• Medicines: Sildenafil citrate 100 mg + Tadalafil 20 mg
• What it’s for: Erectile dysfunction (ED)
• How it helps: Improves blood flow to the penis during sexual stimulation
• When it works: Often within ~30–60 minutes; may last longer depending on the person
• Key cautions: Do not combine with nitrates or “poppers”; caution with heart disease and blood-pressure medicines

Basic product information

How Sildalis works (mechanism of action)

Erection occurs when sexual stimulation leads to increased blood flow to the penis. The process involves a chemical signal pathway inside penile tissue. Two key enzymes—PDE5 (phosphodiesterase type 5)—help break down a natural messenger called cGMP, which relaxes blood vessels and supports blood flow.

Sildenafil and tadalafil are both PDE5 inhibitors. By blocking PDE5, they help:

• Preserve cGMP levels in penile tissue
• Promote relaxation of blood vessel walls
• Increase and maintain blood flow during sexual stimulation

Important: PDE5 inhibitors do not cause an erection by themselves. They work best when you are sexually stimulated.

Pharmacokinetics (how the body processes it)

Pharmacokinetics describes absorption, distribution, metabolism, and elimination. Because Sildalis contains two PDE5 inhibitors, you may experience effects that reflect the action of both components.

Sildenafil (from sildenafil citrate)

• Absorption: Absorbs after oral dosing; peak levels are reached within about 1 hour (can vary).
• Onset: Often within 30–60 minutes.
• Duration: Typically several hours, depending on the individual and food effects.
• Metabolism: Primarily by liver enzymes (notably CYP3A4).
• Excretion: Metabolites are eliminated mainly via faeces and urine.

Tadalafil (from tadalafil)

• Absorption: Absorbs after oral dosing; peak levels are often reached within 1–2 hours.
• Onset: Frequently begins within 30 minutes and can be gradual.
• Duration: Known for a longer effect profile, commonly up to 36 hours in many users (varies).
• Metabolism: Primarily by liver enzymes (notably CYP3A4/5).
• Excretion: Metabolites are eliminated mainly via faeces and urine.

Because both ingredients are processed by the liver and can interact with other medicines, it is important to consider drug interactions (see “Alcohol and medicine interactions” below).

Typical use and indications

Sildalis is indicated for the treatment of erectile dysfunction (ED)—the consistent inability to achieve or maintain an erection sufficient for satisfactory sexual performance.

ED can have many causes, including blood vessel problems, nerve issues, hormonal factors, psychological factors, and medication side effects. If ED is new, worsening, or associated with chest pain or breathlessness, seek medical advice.

How and when to take Sildalis (timing)

The optimal timing depends on your body, the reason for ED, and whether you eat before taking the tablet. Sildalis is taken by mouth.

General timing guidance

• Typical onset: Often within 30–60 minutes (varies).
• Planning: Many people prefer taking it about an hour before planned sexual activity.
• Longer window: Thanks to tadalafil’s longer action, some people may find it helpful over a wider time frame.

Follow the product-specific instructions provided by the supplier and your healthcare professional. Do not increase the dose to “make it work” sooner—doing so can increase side effects.

Dosing information (important)

Sildalis contains high-dose PDE5 inhibitors in a single product (sildenafil 100 mg + tadalafil 20 mg). The correct dose depends on individual factors such as age, liver and kidney function, and other medicines.

For safety, it is essential to follow approved guidance for the specific product and your clinician/pharmacist’s advice.

Missed dose

This medicine is used when needed for sexual activity. There is no “missed dose” in the usual sense.

Maximum frequency

Do not take more frequently than advised for your condition and risk profile. Taking PDE5 inhibitors too often increases the likelihood of adverse events, including low blood pressure, dizziness, and fainting.

Food interactions and effects

Food can influence absorption—especially for sildenafil. In general:

• Large or high-fat meals: May delay onset and reduce effectiveness of sildenafil in some users.
• Smaller meals / lighter foods: May allow a more predictable onset.

If you notice reduced effects after heavy meals, try taking Sildalis with a lighter meal or on a more fasting-like schedule (while still maintaining your usual health advice).

Alcohol: what to know

Alcohol can worsen erectile performance by affecting blood flow, nerve signalling, and self-control/sexual arousal. It can also increase the risk of dizziness and low blood pressure when combined with PDE5 inhibitors.

• Limit alcohol: Keep alcohol moderate, especially for the first time you use Sildalis.
• Hydration: Drink water and avoid excessive alcohol consumption.
• Be cautious with driving: If you feel light-headed, do not drive or operate machinery.

Medicine interactions (very important)

Sildalis can interact with several medicines. Some interactions may be dangerous. Discuss your medication list (including “over-the-counter” products and supplements) with a healthcare professional or pharmacist.

Absolute contraindications / do-not-combine

Do not use PDE5 inhibitors with the following:

• Nitrates (e.g., glyceryl trinitrate/nitroglycerin, isosorbide): risk of severe hypotension.
• “Poppers” (amyl nitrite, similar nitrite inhalants): also associated with dangerous blood pressure drops.

Blood-pressure medicines and alpha-blockers

• Alpha-blockers (for prostate symptoms or blood pressure): can increase the risk of dizziness or fainting, particularly when starting therapy or adjusting doses.
• Other antihypertensives: may add to the blood-pressure-lowering effects.

Medicines that affect liver enzymes (CYP3A4)

Sildenafil and tadalafil are metabolised by liver enzymes, notably CYP3A4. Medicines that strongly inhibit or induce these enzymes may change Sildalis levels.

• Strong CYP3A4 inhibitors may increase PDE5 inhibitor exposure and side effects (e.g., some antifungals and certain antivirals).
• Some antibiotic/antifungal and antiviral treatments can also increase levels.
• Enzyme inducers may reduce effectiveness.

If you are taking HIV medications, certain antifungals, macrolide antibiotics, or other strong interacting medicines, seek specific advice before using Sildalis.

Other erectile dysfunction treatments

Do not combine Sildalis with other PDE5 inhibitors (or other ED treatments that affect the same pathway) unless specifically advised. Combining may increase the risk of side effects without improving safety.

Riociguat and similar medicines

Riociguat (used for certain lung and blood pressure conditions) can interact with PDE5 inhibitors and should not be used together.

Medicines for erectile dysfunction complications

If you use treatments such as penile injections or vacuum devices, discuss scheduling and safety with a clinician. The best approach depends on your diagnosis and risk factors.

Safety profile and potential side effects

Like all medicines, Sildalis can cause side effects. Many are mild and temporary, but some can be serious. Seek urgent medical attention if you experience severe or concerning symptoms.

Common side effects

• Headache
• Flushing (warmth/redness)
• Indigestion or nausea
• Dizziness or light-headedness
• Blocked or runny nose
• Back pain or muscle aches (more typical of tadalafil)
• Visual changes such as mild blurring (rare)

Seek urgent help

• Chest pain or symptoms of a heart problem during sexual activity.
• Fainting or severe dizziness.
• Sudden hearing loss or severe ringing in the ears.
• Sudden vision loss or serious eye pain.
• Prolonged erection (priapism) lasting more than 4 hours—this is a medical emergency.

Who should be extra cautious?

Extra caution is needed if you have:

• Heart disease or a history of severe cardiovascular events
• Low blood pressure or dehydration
• Stroke or significant neurological disease
• Severe liver impairment (risk of higher exposure)
• Severe kidney impairment
• Retinitis pigmentosa (rare eye condition)
• History of priapism

Practical use tips (to improve results and minimise risk)

• Start with a plan: Choose a time when you are unlikely to be rushed, and allow enough time for onset.
• Keep interactions in mind: Check for nitrates, “poppers,” and known interacting medicines.
• Avoid heavy meals: If onset seems delayed, try taking it with a lighter meal.
• Don’t mix with excessive alcohol: It can reduce effectiveness and increase dizziness.
• Use sexual stimulation: PDE5 inhibitors work best with natural arousal.
• Monitor your body: If you feel unusually dizzy or unwell, stop sexual activity and seek medical advice.
• Be patient: If it’s your first time, effectiveness can vary based on stress, sleep, and underlying ED causes.

Alternative options

If Sildalis is not suitable, there are other evidence-based approaches to ED. Alternatives can include:

Other PDE5 inhibitors (single-ingredient options)

• Sildenafil-only products (often shorter onset/duration profile)
• Tadalafil-only products (often longer window)

Depending on your needs, a single-ingredient medicine may provide a more tailored effect with fewer variables.

Non-medicine options

• Lifestyle changes: improving sleep, reducing smoking, managing weight, and increasing activity
• Psychosexual support: stress and anxiety are common contributors
• Medical assessment: review diabetes, blood pressure, cholesterol, testosterone (if appropriate), and medication side effects
• Devices and specialist treatments: vacuum erection devices, penile injections, or referral to a specialist

Market and legal context for Australia (overview)

Medicines for erectile dysfunction are regulated in Australia. Availability and supply can depend on how a product is classified (e.g., whether it is scheduled as prescription-only or supplied under other regulatory pathways) and the requirements of the TGA (Therapeutic Goods Administration).

When purchasing ED medicines online, ensure:

• The supplier is reputable and operates in accordance with Australian requirements
• Product information is clear about active ingredients, strength, and manufacturing
• There is transparency about delivery times and returns/refunds
• Packaging and labelling are consistent and include suitable information

Please note: ED symptoms can also signal underlying health issues (e.g., cardiovascular disease). If you have chest pain, breathlessness, fainting, or severe dizziness, seek medical attention promptly.

Recent guidance and safety considerations

Guidance for PDE5 inhibitors commonly emphasises:

• Do-not-combine rules with nitrates and related agents
• Assessing cardiovascular fitness for sexual activity
• Caution with drug interactions, especially medicines affecting CYP3A4 metabolism
• Monitoring side effects and stopping if serious symptoms occur

Always review your current medication list and any new medicines or changes to health before using Sildalis.

Delivery and availability (Australia)

Sildalis availability can vary by supplier and stock levels. Typical online pharmacy processes in Australia include:

• Order processing: confirmation and payment processing
• Dispatch: usually within 1–2 business days (varies)
• Delivery time: depends on your location (metro vs regional)
• Tracking: often provided
• Packaging: discreet and secure packaging where offered

For the most accurate information on delivery times, shipping costs, and stock status, check the product listing and checkout details.

FAQ

1) What is Sildalis used for?

Sildalis is used to treat erectile dysfunction (ED) by helping increase blood flow to the penis during sexual stimulation.

2) How quickly does it work?

Many people notice effects within 30–60 minutes. Timing can vary, particularly if you eat a heavy or high-fat meal. Because tadalafil is included, some may find it helpful over a longer period.

3) How long does it last?

Duration varies by person. Tadalafil is known for a longer window (commonly up to 36 hours in many users), while sildenafil typically has a shorter effect. Your experience may differ.

4) Can I take it with food?

It can be taken with or without food, but a heavy meal may delay onset or reduce sildenafil effectiveness. If you notice delayed effects, try taking it with a lighter meal.

5) Can I drink alcohol?

Moderate alcohol is generally less likely to cause problems than heavy drinking, but alcohol can worsen erections and increase risks of dizziness and low blood pressure. Keep alcohol limited and avoid excessive consumption.

6) What medicines should I avoid?

Do not use Sildalis with nitrates (including many heart medications) or “poppers”. Be cautious and seek advice if you take alpha-blockers, antihypertensives, or medicines that affect liver metabolism (e.g., strong CYP3A4 inhibitors).

7) What if it doesn’t work?

ED can have multiple causes. If Sildalis does not help, avoid increasing the dose on your own. Consider discussing: underlying health factors, medication interactions, timing, and whether a different PDE5 inhibitor or non-medicine approach may suit you better.

8) What side effects are normal?

Common effects include headache, flushing, blocked nose, indigestion, dizziness, and sometimes back pain or muscle aches. If you experience severe symptoms, chest pain, fainting, vision or hearing problems, or an erection lasting more than 4 hours, seek urgent medical care.

9) Can women or children take it?

Sildalis is intended for adult men with ED. It should not be used by women or children unless specifically directed by a healthcare professional.

10) Is it safe to use every time I have sex?

Safety depends on your health profile and the dosing frequency recommended for the specific product. Do not take PDE5 inhibitors more frequently than advised. If you plan regular use, discuss an appropriate regimen with a healthcare professional.

Important reminder

ED medicines can affect blood pressure and interact with other medications. If you have heart disease, take nitrates, or have concerns about medication interactions, do not take Sildalis without appropriate medical guidance.